What is Simparica Trio for Dogs?

“Simparica Trio” is a parasiticidal medication for dogs that is effective against both internal (endoparasitic) and external (ectoparasitic) parasites. This tablet is primarily used for protecting dogs from parasitic infestations. Simparica Trio tablets are administered to dogs aged 8 weeks or older.

This medication works against external parasites such as ticks, mites, lice, and flies, as well as internal parasites like tapeworms (Cestodes), roundworms (Nematodes) such as Ascaris, lungworm, and heartworm (Dirofilaria immitis). By using Simparica Trio, dogs can be safeguarded against the harmful effects of parasites.

Simparica Trio has limited effectiveness against adult heartworms. This drug is manufactured by Zoetis and is approved by the US FDA.

Simparica Trio is composed of three active ingredients: Sarolaner, Moxidectin, and Pyrantel Pamoate. These ingredients collectively help protect pets from parasitic infestations.

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Composition of Simparica Trio for Dogs

“Simparica Trio tablet” is an antiparasitic dewormer for dogs that acts against both internal and external parasites. It is a tasty, chewable tablet administered to dogs aged 8 weeks or older. Simparica Trio is formulated with a combination of three medicines.

Simparica Trio Per Tablet Contains:

✅ Sarolaner – 0.54 mg/lb (1.2 mg/kg)
✅ Moxidectin – 0.011 mg/lb (24 μg/kg)
✅ Pyrantel (Pamoate Salt) – 2.27 mg/lb (5 mg/kg)

Key Ingredients Information

✅Sarolaner:

• It is a parasiticide belonging to the Isoxazoline class.
• Used for eliminating fleas and ticks in dogs.
• Isoxazoline is a class of five-membered heterocyclic chemical compounds. Its chemical name is 1-[5′-[(5S)-5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]spiro[azetidine-3,1′(3′H)-isobenzofuran]-1-yl]-2-(methylsulfonyl)-ethanone.
• It contains one nitrogen and one oxygen atom.
• Used as an ectoparasiticide in both animals and humans.

Usage:

1. Ectoparasiticide:

• The Isoxazoline class of insecticides was discovered by Nissan.
• Fluralaner, Lotilaner, Afoxolaner, and Sarolaner are used for treating fleas, ticks, and mites in dogs and cats.
• Among them, Afoxolaner and Sarolaner are specifically used for dogs, while others are used as insecticides in agriculture.

✅Moxidectin:

• It is a macrolide compound derived from the fermentation of Streptomyces cyaneogriseus bacteria.
• Its chemical name is (6R,23E,25S)-5-O-Demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-(methoxyimino)milbemycin B.
• A deworming medicine used in dogs, cats, horses, cattle, and sheep against internal parasites such as heartworm, lungworm, Strongylus vulgaris, and intestinal worms.

Usage of Moxidectin:

In Dogs:

Moxidectin is used to prevent heartworms (Dirofilaria immitis) and mite infections such as demodex mange and ear mites.

In Horses:

Moxidectin is used to eliminate Strongylus vulgaris (Roundworm/Nematode).

In Cattle:

Moxidectin is used to control lungworm (Dictyocaulus viviparus) and abomasum worm (Haemonchus).

In Sheep and Goats:

Moxidectin is used as an internal antiparasitic against roundworms/nematodes.

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✅ Pyrantel (Pamoate Salt):

Pyrantel belongs to the Tetrahydropyrimidine class. Its chemical name is (E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl) vinyl] pyrimidine 4,4’ methylenebis [3-hydroxy-2-naphthoate] (1:1).

It is used as an anthelmintic (anti-parasitic agent) against internal parasites such as:

• Ascariasis
• Hookworm Infection
• Enterobiasis (Pinworm Infection)
• Trichostrongyliasis
• Trichinellosis

In dogs, Pyrantel is particularly effective against Roundworms and Hookworms.

Key Features of Simparica Trio Tablet

✅ Triple Protection in One Tablet – Effective against Ticks, Heartworms, and Intestinal Worms, offering comprehensive internal and external parasite control (Ectoparasiticides with Endoparasiticides).

✅ Easy to Chew and Palatable – Specially designed for dogs to consume easily without resistance.

✅ Pyrantel (Pamoate Salt) is a yellow crystalline substance that is insoluble in water.

✅ It is composed of Tetrahydropyrimidine Base (alkali) and Pamoic Acid, with 34.7% base activity.

✅ This means that the active Pyrantel component constitutes 34.7% of the total weight, making it highly effective against parasitic worms.

Mechanism of Simparica Trio for Dogs (Mode of Action)

“Simparica Trio” is primarily composed of three active ingredients: Sarolaner, Moxidectin, and Pyrantel Pamoate. These components work together to protect pets from parasites. Below is a detailed explanation of their mechanisms of action:

1. Sarolaner

• Type: Insecticide and Acaricide
• Class: Isoxazoline
• Mechanism of Action:
  • Sarolaner inhibits GABA and Glutamate receptors, disrupting the nervous system of parasites and leading to their elimination.
  • This interference causes uncontrolled nerve and muscle activity, ultimately resulting in the parasite’s death.

2. Moxidectin

• Type: Endectocide
• Class: Macrocyclic Lactone
• Mechanism of Action:
  • Moxidectin blocks chloride channel-mediated neurotransmission in parasites, leading to their paralysis.
  • As a result, the affected parasites become immobilized and eventually die.

3. Pyrantel Pamoate

• Type: Nematocide
• Class: Tetrahydropyrimidine
• Mechanism of Action:
  • Pyrantel Pamoate disrupts the nerve signals of parasites, causing paralysis.
  • Due to paralysis, parasites either die or are expelled from the body.

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Why Simparica Trio is Effective for Dogs?

• Comprehensive Protection: Works against fleas, ticks, heartworms, and intestinal worms.
• Fast-Acting & Long-Lasting: Provides month-long protection with a single chewable tablet.
• Safe & Palatable: Designed for easy consumption by dogs

Uses of Simparica Trio in Dogs

Simparica Trio is a broad-spectrum medication that effectively works against both internal (Endoparasites) and external (Ectoparasites) parasites in dogs.

1. External Parasites (Ectoparasites)

✅ Ticks – Effective against Ixodidae (hard ticks) and Argasidae (soft ticks).
✅ Mites – Treats Demodectic Mange and Ear Mange infections.
✅ Lice – Prevents Pediculosis infection.
✅ Flies – Prevents Myiasis infections.
✅ Protection Against Lyme Disease – Lyme disease, caused by the Borrelia burgdorferi bacterium and transmitted through tick bites.

2. Internal Parasites (Endoparasites)

✅ Tapeworms (Cestodes)
✅ Roundworms (Nematodes) – Including Ascaris and Lung Worm
✅ Prevention of Heartworm (Dirofilaria immitis) infection

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What are Parasites?

Parasites are organisms that depend on a host for survival, feeding on its nutrients and completing their life cycle. The infestation caused by parasites can severely affect the host’s health.

1. External Parasites (Ectoparasites)

These parasites live on the skin of dogs and can cause various infections.

✅ Ticks

Ticks attach to a dog’s skin and suck blood, leading to anemia and other diseases. Tick infestations are referred to as Tick Worry.

✔ Main Types:

• Ixodidae (Hard Ticks)
• Argasidae (Soft Ticks)

✔ Harmful Effects:

• Ticks cause wounds on the skin, leading to bacterial and viral infections.
• Excessive blood loss can weaken dogs and cause anemia.
• Repeated tick bites may lead to Dermatitis (skin inflammation).
• Ticks are carriers of protozoal diseases such as Babesiosis and Theileriosis.

✔ Tick Prevention and Treatment with Simparica Trio:
Effective against various tick species, including:

• Amblyomma americanum (Lone star tick)
• Amblyomma maculatum (Gulf Coast tick)
• Dermacentor variabilis (American dog tick)
• Ixodes scapularis (Black-legged tick)
• Rhipicephalus sanguineus (Brown dog tick)
• Haemaphysalis longicornis (Asian longhorned tick)

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✅ Mites – Mange Infection

Mange is a skin disease caused by mites.

✔ Demodectic Mange

• Cause: Demodex Canis Mite
• Common in Puppies (3-9 months old)
• Symptoms:
  • Hair loss (Alopecia)
  • Wrinkled and red skin (Red Mange)
  • Severe weakness

✔ Ear Mange (Ear Infection)

• Cause: Otodectes Cynotis
• Symptoms:
  • Constant itching, leading to ear inflammation (Otitis)
  • Excessive ear rubbing, which may cause injuries

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✅ Lice – Pediculosis Infection

• Lice feed on blood and lymph, causing severe itching in dogs.
• Infected dogs tend to rub their bodies against hard surfaces.
• A female louse has a one-month lifespan and spreads rapidly.
• Hair loss is a common symptom of lice infestation.

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✅ Flies – Myiasis Infection

Flies contribute to the spread of protozoal diseases like Leishmaniasis.

Types of Leishmaniasis:

• Visceral Leishmaniasis – Also known as Black Fever (Kala Azar).
• Cutaneous Leishmaniasis – Causes skin ulcers and lesions.
• Mucocutaneous Leishmaniasis – Affects the mucous membranes of the nose, mouth, and throat.
• Transmitted by: Phlebotomine Sandfly.

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2. What are Internal Parasites (Endoparasites)?

Internal parasites infect organs such as the stomach, liver, heart, intestines, and lungs, causing severe health issues in dogs.

Types of Endoparasites and Their Examples:

✅ Flukes
✅ Tapeworms (Taenia Multiceps)
✅ Roundworms (Heartworm, Hookworm)

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✅Roundworms (Nematodes)

Roundworms, also called Nematodes, are internal parasites found in the stomach, intestines, lungs, and heart of dogs, cattle, sheep, goats, and horses.

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✅Heartworm Infection in Dogs

• Parasite Name: Dirofilaria immitis
• Other Names: Heartworm, Dog Heartworm
• Structure: A thin, thread-like filarial worm
• Disease Caused: Dirofilariasis
• Mode of Transmission: Spread through mosquito bites from one dog to another.
• Impact on Dogs:
  • Heartworms reside in the heart and pulmonary arteries, blocking blood flow.
  • This increases pressure on the heart, leading to heart failure and potentially death.

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✅Toxocara canis Infection (Ascarid Infection in Dogs)

• Toxocara canis primarily affects the intestines of dogs.
• Delays growth rate in young puppies.
• Common in 2-week to 2-month-old puppies.
• Transmission Routes:
  • Through the placenta (before birth)
  • Through mother’s milk
• Zoonotic Risk:
  • Toxocara canis can infect humans, causing Toxocariasis.
  • The parasite’s eggs are excreted in dog feces, contaminating the environment and spreading to humans, birds, and healthy animals.

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✅Hookworm Infection in Dogs

Hookworms are roundworm (Nematode) parasites that primarily infect the intestines and disrupt blood supply.

Main Hookworm Parasites:

✅ Ancylostoma caninum (L4 stage, immature and adult worms)
✅ Uncinaria stenocephala (Adult worms)

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✅Taenia Multiceps Infection in Dogs

• Taenia multiceps is a tapeworm with a ribbon-like structure.

Mode of Transmission:

• The adult Taenia multiceps parasite is found in the intestines of dogs.
• Intermediate host: Sheep.
• Causes a neurological disease (Coenurus cerebralis) in sheep.

Symptoms of ‘Gid Disease’ in Sheep:

• Infected sheep walk in circles.
• Press their heads against walls.
• Loss of balance and coordination.

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Why Use Simparica Trio for Parasite Control?

• Protects against multiple parasites, including fleas, ticks, mites, lice, worms, and heartworms.
• Prevents severe diseases like Lyme Disease, Dirofilariasis, and Mange.
• Easy-to-administer chewable tablet with long-lasting effects.

Which Dogs Should Be Given Simparica Trio?

✅ Puppies and dogs aged 8 weeks or older can be given Simparica Trio.
✅ Minimum weight requirement: Dogs must weigh at least 2.8 pounds (1.3 kg).
✅ This medication provides one-month protection against heartworms, intestinal worms, fleas, and ticks.

Simparica Trio is an all-in-one treatment, proven effective in protecting dogs from both external and internal parasites.

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Simparica Trio Dosage and Administration

How to Administer Simparica Trio to Dogs?

• Simparica Trio is primarily administered orally (Oral Route), per-oral (Per Oral), or enterally (Enteral Route).
• Anthelmintic (anti-parasitic) medications are usually given orally because parasites mainly reside in the stomach, intestines, liver, and other internal organs.
• For best results, Simparica Trio should be given on an empty stomach or before meals.
• Consult your veterinarian to determine the correct dosage and timing based on your dog’s specific needs.

Dosage Calculation Per kg:

• Sarolaner: 1.2 mg/kg
• Moxidectin: 0.024 mg/kg (24 μg/kg)
• Pyrantel: 5 mg/kg

Dosage Calculation Per lbs:

• Sarolaner: 0.54/lbs
• Moxidectin: 0.011 mg/lbs
• Pyrantel: 2.27 mg/lbs

Functions of Simparica Trio in Dogs

1. Effective Against Heartworm (Dirofilaria immitis)

✔️ This medication helps prevent and control heartworm infections in dogs.
✔️ It should be administered monthly, year-round, ensuring regular deworming for your pet.

2. Helps in Flea Treatment and Prevention

✔️ Can be started at any time for flea control.
✔️ Should be administered every month throughout the year or one month before flea season begins.

3. Aids in Tick Control and Treatment

✔️ Should be given monthly, year-round or one month before tick season starts for effective prevention.

4. Protects Against Intestinal Worms

✔️ Simparica Trio prevents and treats Roundworms and Hookworms.
✔️ A single dose is usually sufficient for deworming.

5. Effective Against Tapeworm Infections

✔️ Simparica Trio also helps in the treatment of tapeworm infestations in dogs.

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⚠️ Warnings for Simparica Trio Usage in Dogs

🚫 Not for Human Use: This medication is exclusively for dogs and should not be used by humans.

👶 Keep Away from Children: As with all medications, store Simparica Trio in a safe place, out of children’s reach.

🐾 Prevent Overdose in Pets: Ensure that cats, other dogs, or household pets do not accidentally consume this medication.

⚠️ If ingested accidentally by a human or another pet, seek immediate medical or veterinary assistance.

⚠️ Precautions for Using Simparica Trio in Dogs

🧠 Effects on the Nervous System

Sarolaner, a key ingredient in Simparica Trio, belongs to the Isoxazoline class of compounds.
Medications in this class may cause the following neurological side effects in dogs:

✔️ Tremors
✔️ Loss of coordination (Ataxia)
✔️ Seizures or dizziness

⚠️ Special Caution:

• If your dog already has epilepsy (seizures) or other neurological disorders, use this medication with extreme caution.
• Vitamin B1 (Thiamine) Deficiency: Ensure that dogs with a Vitamin B1 deficiency receive adequate supplementation before administering Simparica Trio.

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❤️ Heartworm Infection Testing is Essential

Before giving “Simparica Trio”, your dog must be tested for Heartworm infection (Dirofilaria immitis).

✔️ If your dog already has a heartworm infection, treat it first with a medication that eliminates adult heartworms before using Simparica Trio.
✔️ Simparica Trio does not kill adult heartworms, so it should not be used as a treatment for existing infections.

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🐶 Safety in Breeding, Pregnant, and Lactating Dogs is Unknown

✔️ The safety of Simparica Trio in breeding, pregnant, or lactating dogs has not been fully established.
✔️ Consult a veterinarian before using this medication in such cases.

Adverse Reactions of Simparica Trio in Dogs

According to a safety study, side effects such as vomiting, diarrhea, and increased thirst were observed in dogs.

Study Details:

• Total number of dogs: 410
  ✔️ Treatment duration: 11 months (one dose per month)
  ✔️ Group division:
  • Treated with Simparica Trio: 272 dogs
  • Active control group: 138 dogs
    ✔️ Observation period: 330 days

Other Studies:

✔️ In a study with 278 flea-infested dogs, diarrhea was observed.
✔️ In a study with 120 dogs with roundworm infection, vomiting and diarrhea were seen.
✔️ In a controlled laboratory study, a dog experienced a seizure 16 days after taking Simparica Trio.

Common Side Effects of Simparica Trio

Most Frequently Reported Side Effects

📌 Vomiting – 14.3%
📌 Diarrhea – 13.2%
📌 Lethargy (Fatigue/Weakness) – 8.5%
📌 Loss of Appetite (Anorexia) – 5.1%
📌 Frequent Urination (Polyuria) – 3.7%
📌 Hyperactivity – 2.2%
📌 Increased Thirst (Polydipsia) – 2.2%

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Less Common but Reported Side Effects

⚠️ Seizures – Observed in controlled studies, although considered rare.

What to Do if Side Effects Occur from Simparica Trio?

1. Report Immediately:
   If any side effects are noticed during the use of Simparica Trio tablets, report them immediately to Zoetis and the FDA. This will allow for in-depth study and appropriate solutions.
2. Report to Zoetis:
   Zoetis, the manufacturer of Simparica Trio, can be reached at 1-888-963-8471 to report side effects.
3. Report Directly to FDA:
   You can submit a side effect report directly to the FDA at www.fda.gov/reportanimalae.
4. Include in the Report:
   To make the report effective and accurate, include the following information:

• Full medical history of the dog.
• How many times Simparica Trio was administered.
• The dog’s age and any pre-existing conditions.
• The lot number of the tablet vial used.

Discover NSTFDC (New Simparica Trio For Dogs Care) , your trusted guide to Simparica Trio—a powerful parasiticidal medication that protects dogs from fleas, ticks, heartworms, and intestinal parasites. Stay informed for your pet’s health!

NSTFDC (New Simparica Trio For Dogs Care)